Novel Secreted Protein Kinases

Novel Secreted , Ameloblast - specific Protein − −

P20: The Role of Protein Kinases in Memory

When an experience is encrypted into a long-lasting memory, it is believed that specific sets of neurons in the brain of the animal undergo changes including the strengthening of preexisting synapses and the growth and maintenance of new synaptic connections. These activity-dependent synaptic changes appear to require the coordination of a variety of cellular processes in spatially separated ce...

MAPK-Activated Protein Kinases (MKs): Novel Insights and Challenges

Downstream of MAPKs, such as classical/atypical ERKs and p38 MAPKs, but not of JNKs, signaling is often mediated by protein kinases which are phosphorylated and activated by MAPKs and, therefore, designated MAPK-activated protein kinases (MAPKAPKs). Recently, novel insights into the specificity of the assembly of MAPK/MAPKAPK hetero-dimeric protein kinase signaling complexes have been gained. I...

Alpha-kinases: a new class of protein kinases with a novel catalytic domain

Colin Blakemore What is your advice to a neuroscience PhD student? Think long and hard about whether you want to commit yourself to a career in scientific neuroscience. There are limited resources, grants, jobs and ideas. The sort of people who can’t live without research are the sort of people who will have the enthusiasm to continue. Also, it is very easy to get bogged down in the intricacies...

Atypical Protein Kinases (aPKs)

Atypical protein kinases lack sequence similarity to the ePK domain HMM profile, but have been shown experimentally to have protein kinase activity, or are clear homologs of aPKs with demonstrated protein kinase activity. All aPK families are small, several having just one member in vertebrates, and none in invertebrates. Other aPK families may remain to be discovered by biochemical methods, bu...